重组星形胶质细胞PEA15蛋白

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重组星形胶质细胞PEA15蛋白

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

重组磷酸化星形胶质细胞PEA15蛋白
Recombinant PEA15

基因名：

PEA15

产品别名：

HMAT1； HUMMAT1H； MAT1； MAT1H； PEA-15； PED； PED-PEA15； PED/PEA15； PEA15； proliferation and apoptosis adaptor protein 15； proliferation and apoptosis adaptor protein 15； astrocytic phosphoprotein PEA-15； 15 kDa phosphoprotein enriched in astrocytes； homolog of mouse MAT-1 oncogene； mammary transforming gene 1, mouse, homolog of； phosphoprotein enriched in astrocytes 15； phosphoprotein enriched in diabetes； proliferation and apoptosis adaptor 15；星形胶质细胞PEA15；磷酸化星形胶质细胞PEA15；

背景信息：

Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。