基因名：
PEA15
产品别名：
HMAT1； HUMMAT1H； MAT1； MAT1H； PEA-15； PED； PED-PEA15； PED/PEA15； PEA15； proliferation and apoptosis adaptor protein 15； proliferation and apoptosis adaptor protein 15； astrocytic phosphoprotein PEA-15； 15 kDa phosphoprotein enriched in astrocytes； homolog of mouse MAT-1 oncogene； mammary transforming gene 1, mouse, homolog of； phosphoprotein enriched in astrocytes 15； phosphoprotein enriched in diabetes； proliferation and apoptosis adaptor 15； 星形胶质细胞PEA15； 磷酸化星形胶质细胞PEA15；
背景信息：
Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
