基因名：
CRADD
产品别名：
MRT34； RAIDD； CRADD； CASP2 and RIPK1 domain containing adaptor with death domain； CASP2 and RIPK1 domain containing adaptor with death domain； death domain-containing protein CRADD； CRADD/LYZ fusion； RIP-associated ICH1/CED3-homologous protein with death domain； caspase and RIP adaptor with death domain； death adaptor molecule RAIDD； death domain containing protein CRADD； CASP2凋亡相关蛋白； 含CASP2和RIPK1域死亡域衔接蛋白(CRADD)；
背景信息：
Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues, with particularly high expression in the adult heart, testis, liver, skeletal muscle, fetal liver, and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2, and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numerous tissues. Defects in CRADD will result in mental retardation.
