基因名：
TNFSF12
产品别名：
APO3L； DR3LG； TNLG4A； TWEAK； TNFSF12； TNF superfamily member 12； TNF superfamily member 12； tumor necrosis factor ligand superfamily member 12； APO3 ligand； APO3/DR3 ligand； TNF-related WEAK inducer of apoptosis； tumor necrosis factor (ligand) superfamily, member 12； tumor necrosis factor ligand 4A； tumor necrosis factor superfamily member 12； 肿瘤坏死因子配体超家族成员12(TNFSF12)；
背景信息：
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.
