基因名：
TNFSF9
产品别名：
4-1BB-L； CD137L； TNLG5A； TNFSF9； TNF superfamily member 9； TNF superfamily member 9； tumor necrosis factor ligand superfamily member 9； 4-1BB ligand； 4-1BBL； CD137 ligand； homolog of mouse 4-1BB-L； receptor 4-1BB ligand； tumor necrosis factor (ligand) superfamily, member 9； tumor necrosis factor ligand 5A； tumor necrosis factor superfamily member 9； TNFSF9(Trimer)蛋白； 肿瘤坏死因子配体超家族成员9； 肿瘤坏死因子配体超家族成员9(TNFSF9)；
背景信息：
Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death (AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction.
