基因名：
FADD
产品别名：
GIG3； IMD90； MORT1； FADD； Fas associated via death domain； Fas associated via death domain； FAS-associated death domain protein； Fas (TNFRSF6)-associated via death domain； Fas-associating death domain-containing protein； Fas-associating protein with death domain； growth-inhibiting gene 3 protein； mediator of receptor-induced toxicity； Fas死亡结构域相关蛋白； 含Fas关联死亡域蛋白(FADD)； 磷酸化Fas死亡结构域相关蛋白； 磷酸化Fas相关死亡结构域蛋白；
背景信息：
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
