基因名：
SIGLEC5
产品别名：
CD170； CD33L2； OB-BP2； OBBP2； SIGLEC-5； SIGLEC5； sialic acid binding Ig like lectin 5； sialic acid binding Ig like lectin 5； sialic acid-binding Ig-like lectin 5； CD33 antigen-like 2； OB-binding protein 2； obesity-binding protein 2； sialic acid-binding immunoglobulin-like lectin 5； siglec 5蛋白； 唾液酸结合Ig样凝集素5(SIGLEC5)； 唾液酸结合性免疫球蛋白样凝集素5；
背景信息：
Human Siglec-5 are Itype(Igtype) lectins belonging to the Ig superfamily,They are characterized by an N terminal Ig-like V type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2 type domains. SIGLEC5 has also been designated CD170, they are expressed by monocytic or myeloid lineage cells, and also found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. SIGLEC5 are expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. One remarkable feature of the CD33 related Siglecs is their differential expression pattern within the hematopoietic system This fact, together with the presence of two conserved immunoreceptor tyrosinebased inhibition motifs (ITIMs) in their cytoplasma tails, suggests that CD33 related Siglecs are involved in the regulation of cellular activation within the immune system.
