基因名：
TNFRSF18
产品别名：
AITR； CD357； ENERGEN； GITR； GITR-D； TNFRSF18； TNF receptor superfamily member 18； TNF receptor superfamily member 18； tumor necrosis factor receptor superfamily member 18； TNF receptor superfamily activation-inducible protein； activation-inducible TNFR family receptor； glucocorticoid-induced TNFR-related protein； 糖皮质激素诱导肿瘤坏死因子受体； 糖皮质激素诱导肿瘤坏死因子受体(GITR)；
背景信息：
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
