重组核因子κB受体激活因子(RANk)蛋白

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重组核转录因子NF-κB受体(核因子kB受体活化因子)蛋白
Recombinant TNFRSF11A

基因名：

TNFRSF11A

产品别名：

CD265； FEO； LOH18CR1； ODFR； OFE； OPTB7； OSTS； PDB2； RANK； TRANCE-R； TRANCER； TNFRSF11A； TNF receptor superfamily member 11a； TNF receptor superfamily member 11a； tumor necrosis factor receptor superfamily member 11A； Paget disease of bone 2； TRANCE receptor； familial expansile osteolysis； loss of heterozygosity, 18, chromosomal region 1； osteoclast differentiation factor receptor； receptor activator of NF-KB； receptor activator of nuclear factor-kappa B； tumor necrosis factor receptor superfamily, member 11a, NFKB activator；核因子κB受体激活因子(RANk)；核转录因子NF-κB受体(核因子kB受体活化因子)；核转录因子NF-κB受体/核因子kB受体活化因子；

背景信息：

Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.