基因名:
IQGAP1
产品别名:
HUMORFA01; SAR1; p195; IQGAP1; IQ motif containing GTPase activating protein 1; IQ motif containing GTPase activating protein 1; ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs; 含IQ基元GTP酶激活蛋白1(IQGAP1); 支架蛋白;
背景信息:
IQGAP1 is a widely expressed protein than interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology. It binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.