基因名:
KAT2B
产品别名:
CAF; P/CAF; PCAF; KAT2B; lysine acetyltransferase 2B; lysine acetyltransferase 2B; histone acetyltransferase KAT2B; CREBBP-associated factor; K(lysine) acetyltransferase 2B; histone acetylase PCAF; histone acetyltransferase PCAF; p300/CBP-associated factor; spermidine acetyltransferase KAT2B; K-乙酰转移酶2B(KAT2B); 组蛋白乙酰转移酶PCAF;
背景信息:
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.