基因名：
PER2
产品别名：
FASPS； FASPS1； PER2； period circadian regulator 2； period circadian regulator 2； period circadian protein homolog 2； circadian clock protein PERIOD 2； hPER2； period 2； period circadian clock 2； period circadian protein 2； period homolog 2； 昼夜节律蛋白2(PER2)； 节律蛋白2；
背景信息：
PER2, a mammalian homologue of the Drosophila period gene, shares a 40% homology with PER1 including the protein dimerization PAS domain. PER2 is a circadian regulator that may act as a transcription factor. It behaves as a negative element in circadian transcriptional loop. PER2 does not appear to bind DNA, suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hour rhythm in the suprachiasmatic nucleus (SCN) and the whole eyes. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between PER1 and PER2 oscillations. The expression rhythms appear to originate from retina.
