基因名：
ARHGEF7
产品别名：
BETA-PIX； COOL-1； COOL1； Nbla10314； P50； P50BP； P85； P85COOL1； P85SPR； PAK3； PIXB； ARHGEF7； Rho guanine nucleotide exchange factor 7； Rho guanine nucleotide exchange factor 7； rho guanine nucleotide exchange factor 7； PAK-interacting exchange factor beta； Rho guanine nucleotide exchange factor (GEF) 7； SH3 domain-containing proline-rich protein； p21活化蛋白激酶ARHG7； Rho鸟嘌呤核苷酸交换因子7(ARHGEF7)；
背景信息：
ARHGEF7 is a p21-activated protein kinase (Pak)-interacting exchange factor that has been identified as a putative guanine nucleotide exchange factor (GEF) for Rac/Cdc42. It is expressed ubiquitously in all the tissue examined and other isoforms are expressed mainly in the central nervous system. Regulated phosphorylation of ARHGEF7 is necessary to maintain the balance between normal signalling by EGFR and Src versus aberrant growth and transformation. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.
