基因名：
SQSTM1
产品别名：
A170； DMRV； FTDALS3； NADGP； OSIL； PDB3； ZIP3； p60； p62； p62B； SQSTM1； sequestosome 1； sequestosome 1； sequestosome-1； EBI3-associated protein of 60 kDa； EBI3-associated protein p60； EBIAP； autophagy receptor p62； oxidative stress induced like； phosphotyrosine independent ligand for the Lck SH2 domain p62； phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa； ubiquitin-binding protein p62； 死骨片1(SQSTM1)； 泛素结合蛋白P62；
背景信息：
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
