基因名：
PHOX2B
产品别名：
CCHS； NBLST2； NBPhox； PMX2B； PHOX2B； paired like homeobox 2B； paired like homeobox 2B； paired mesoderm homeobox protein 2B； PHOX2B homeodomain protein； neuroblastoma Phox； neuroblastoma paired-type homeobox protein； paired like homeobox2B； paired mesoderm homeobox 2b； 神经母细胞瘤蛋白PHOX2B；
背景信息：
Phox2a (also designated Arix1) and Phox2b are closely related, paired-homeodomain transcription factors that are necessary for neuronal differentiation throughout the developing sympathetic, parasympathetic and enteric ganglia. All enteric nervous system cells evolve from the neural crest, and all cells that are undifferentiated initially express Phox2b. The cells that begin to differentiate along a neuronal lineage continue to express Phox2b, and begin to express Phox2a. Phox2b is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, Phox2a controls only the differentiation of the main noradrenergic center of the brain, the locus coeruleus. Both Phox2a and Phox2b are crucial for the regulation of endogenous tyrosine hydroxylase and dopamine-beta hydroxylase, which are transiently expressed in neural crest cells. In addition, Phox2 proteins are sufficient to promote sympathetic neuron generation. The gene which encodes Phox2a maps to human chromosome 11q13.3-q13.4.
