基因名：
SKAP2
产品别名：
PRAP； RA70； SAPS； SCAP2； SKAP-HOM； SKAP55R； SKAP2； src kinase associated phosphoprotein 2； src kinase associated phosphoprotein 2； src kinase-associated phosphoprotein 2； Fyn-associated phosphoprotein SKAP55 homologue； Pyk2/RAFTK-associated protein； SKAP-55HOM； SKAP55 homolog； retinoic acid-induced protein 70； src family-associated phosphoprotein 2； src kinase-associated phosphoprotein of 55-related protein； src-associated adapter protein with PH and SH3 domains； Src家族相关磷酸化蛋白2；
背景信息：
Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
