基因名：
TNFSF18
产品别名：
AITRL； GITRL； TL6； TNLG2A； hGITRL； TNFSF18； TNF superfamily member 18； TNF superfamily member 18； tumor necrosis factor ligand superfamily member 18； AITR ligand； GITR ligand； activation-inducible TNF-related ligand； glucocorticoid-induced TNF-related ligand； glucocorticoid-induced TNFR-related protein ligand； tumor necrosis factor (ligand) superfamily, member 18； tumor necrosis factor ligand 2A； tumor necrosis factor superfamily member 18； 肿瘤坏死因子配体超家族成员18； 肿瘤坏死因子配体超家族成员18(TNFSF18)； 肿瘤坏死因子配体超家族成员18(TNFSF18)真核蛋白；
背景信息：
TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
