基因名：
BRSK2
产品别名：
C11orf7； PEN11B； SAD-A； SAD1； SADA； STK29； BRSK2； BR serine/threonine kinase 2； BR serine/threonine kinase 2； serine/threonine-protein kinase BRSK2； BR serine/threonine-protein kinase 2； brain-selective kinase 2； brain-specific serine/threonine-protein kinase 2； protein kinase SAD1B； serine/threonine-protein kinase 29； serine/threonine-protein kinase SAD-A； testicular tissue protein Li 30； 脑蛋白丝氨酸/苏氨酸激酶29；
背景信息：
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BRSK2 (BR serine/threonine kinase 2), also known as SAD1, STK29 or PEN11B, is a 736 amino acid protein that contains one protein kinase domain and is preferentially expressed in brain and testis. One of several members of the Ser/Thr protein kinase family, BRSK2 uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be involved in microtubule assembly, neuronal polarization and synaptic development. Additionally, BRSK2 may function as an autoantigen involved in small-cell lung cancer-associated limbic encephalitis. Five isoforms of BRSK2 exist due to alternative splicing events.
