基因名：
RNF8
产品别名：
hRNF8； RNF8； ring finger protein 8； ring finger protein 8； E3 ubiquitin-protein ligase RNF8； C3HC4-type zinc finger protein； RING-type E3 ubiquitin transferase RNF8； UBC13/UEV-interacting ring finger protein； ring finger protein (C3HC4 type) 8； ring finger protein 8, E3 ubiquitin protein ligase； 环指蛋白8；
背景信息：
The RING finger motif is a specialized DNA-binding zinc finger domain found in many transcriptional regulatory proteins. The ring finger protein (RNF) family includes any protein containing the signature RING finger motif. RNF8 is a ubiquitously expressed nuclear RING finger protein that acts as an E3 ubiquitin-protein ligase. It is required for the ubiquitination of some nuclear proteins and promotes their subsequent degradation. The heterodimeric ubiquitin-conjugating enzyme UBC13 interacts with RNF8, and they co-localize in the nucleus. RNF8 may regulate mediation of UBC13 polyubiquitylation by elongating the ubiquitin chains. RNF8 also binds to Retinoid X receptor alpha (RXR?, a member of the steroid hormone receptor superfamily. It increases RXR?mediated transactivation of the RXR?responsive element (RXRE) promoter in a dose-dependent manner, suggesting that RNF8 is a regulator of RXR?mediated transcriptional activity.
