基因名：
UBE2M
产品别名：
UBC-RS2； UBC12； hUbc12； UBE2M； ubiquitin conjugating enzyme E2 M； ubiquitin conjugating enzyme E2 M； NEDD8-conjugating enzyme Ubc12； NEDD8 carrier protein； NEDD8 protein ligase； epididymis secretory sperm binding protein； ubiquitin carrier protein M； ubiquitin conjugating enzyme E2M； ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)； ubiquitin-protein ligase M； yeast UBC12 homolog； 泛素蛋白连接酶M；
背景信息：
UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
