基因名：
SPAG9
产品别名：
CT89； HLC-6； HLC4； HLC6； JIP-4； JIP4； JLP； PHET； PIG6； SPAG9； sperm associated antigen 9； sperm associated antigen 9； C-Jun-amino-terminal kinase-interacting protein 4； JNK interacting protein； JNK/SAPK-associated protein； Max-binding protein； c-Jun NH2-terminal kinase-associated leucine zipper protein； cancer/testis antigen 89； human lung cancer oncogene 6 protein； lung cancer oncogene 4； mitogen-activated protein kinase 8-interacting protein 4； proliferation-inducing gene 6； protein highly expressed in testis； sperm surface protein； sunday driver 1；
背景信息：
JIP-4 is a 1,321 amino acid protein encoded by the human gene SPAG9. It contains a large N-terminal extracellular domain, a short transmembrane helical domain, and a cytoplasmic domain. There are 6 N-glycosylation sites, several phosphorylation sites for cAMP/cGMP-dependent protein kinase, protein kinase C, and casein kinase II, and 10 putative myristoylation sites. There is also a leucine zipper motif, with 6 leucine repeats, that may aid in dimerization since there is no upstream basic domain characteristic of DNA binding proteins. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP-4 is a cytoplasmic, perinuclear protein that has eight known isoforms whose expression varies by tissue and disease state.
