基因名：
GPRC5A
产品别名：
GPCR5A； PEIG-1； RAI3； RAIG1； TIG1； GPRC5A； G protein-coupled receptor class C group 5 member A； G protein-coupled receptor class C group 5 member A； retinoic acid-induced protein 3； G-protein coupled receptor family C group 5 member A； TPA induced gene 1； orphan G-protein-coupling receptor PEIG-1； phorbol ester induced gene 1； phorbol ester induced protein-1； retinoic acid induced 3； retinoic acid responsive； retinoic acid-induced gene 1 protein； G蛋白偶联受体家族C5组成员A(GPRC5A)； 维甲酸诱导蛋白3；
背景信息：
RAI3 is an transmembrane G-protein-coupled receptor that affects many essential biological processes including embryogenesis, cell growth, differentiation, and apoptosis. RAI3 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate RAI3 during its transcription in embryonal carcinoma differentiation. RAI3 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of RAI3 and represses its expression at the beginning of apoptosis. RAI3 is a potential molecular target for diagnosing breast cancer, and selective suppression of signals from RAI3 may have a place in breast cancer treatments.
