基因名：
DYRK1B
产品别名：
AOMS3； MIRK； DYRK1B； dual specificity tyrosine phosphorylation regulated kinase 1B； dual specificity tyrosine phosphorylation regulated kinase 1B； dual specificity tyrosine-phosphorylation-regulated kinase 1B； dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B； minibrain-related kinase； mirk protein kinase； 双特异性酪氨酸磷酸化调节激酶1B；
背景信息：
Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is self regulated by tyrosine phosphorylation. Several related mammalian proteins compose the Dyrk family of dual specificity protein kinases, including Dyrk1A, Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B. The Dyrk family members are thought to be involved in the regulation of cellular growth and/or development. Dyrk1B localizes to the nucleus in muscle and testis. Specifically, Dyrk1B plays a critical role in muscle differentiation by regulating motility, transcription, cell cycle progression and cell survival. Dyrk1B is also found is several solid tumors, where it acts as a downstream effector of Rac1 or K-ras to mediate cell survival.
