基因名：
BUB3
产品别名：
BUB3L； hBUB3； BUB3； BUB3 mitotic checkpoint protein； BUB3 mitotic checkpoint protein； mitotic checkpoint protein BUB3； BUB3 budding uninhibited by benzimidazoles 3 homolog； budding uninhibited by benomyl； budding uninhibited by benzimidazoles 3 homolog； mitotic checkpoint component； testicular tissue protein Li 27； 有丝分裂蛋白BUB3；
背景信息：
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
