基因名：
AIMP1
产品别名：
EMAP2； EMAPII； HLD3； SCYE1； p43； AIMP1； aminoacyl tRNA synthetase complex interacting multifunctional protein 1； aminoacyl tRNA synthetase complex interacting multifunctional protein 1； aminoacyl tRNA synthase complex-interacting multifunctional protein 1； ARS-interacting multifunctional protein 1； endothelial monocyte-activating polypeptide 2； endothelial-monocyte activating polypeptide II； multisynthase complex auxiliary component p43； multisynthetase complex auxiliary component p43； small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)； 内皮单核细胞激活肽2； 氨酰tRNA合成酶复合多功能相互作用蛋白1(AIMP1)；
背景信息：
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
