基因名：
COPS2
产品别名：
ALIEN； CSN2； SGN2； TRIP15； COPS2； COP9 signalosome subunit 2； COP9 signalosome subunit 2； COP9 signalosome complex subunit 2； COP9 constitutive photomorphogenic homolog subunit 2； JAB1-containing signalosome subunit 2； TR-interacting protein 15； TRIP-15； alien homolog； signalosome subunit 2； thyroid receptor-interacting protein 15； 甲状腺受体15； 甲状腺激素受体相互作用15；
背景信息：
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
