基因名：
EIF2AK3
产品别名：
PEK； PERK； WRS； EIF2AK3； eukaryotic translation initiation factor 2 alpha kinase 3； eukaryotic translation initiation factor 2 alpha kinase 3； eukaryotic translation initiation factor 2-alpha kinase 3； PKR-like ER kinase； PRKR-like endoplasmic reticulum kinase； pancreatic EIF2-alpha kinase； pancreatic eIF-2alpha kinase； 真核翻译起始因子2α激酶3(EIF2aK3)； 磷酸化蛋白激酶样内质网激酶； 蛋白激酶样内质网激酶；
背景信息：
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010].
