基因名：
HAND2
产品别名：
DHAND2； Hed； Thing2； bHLHa26； dHand； HAND2； heart and neural crest derivatives expressed 2； heart and neural crest derivatives expressed 2； heart- and neural crest derivatives-expressed protein 2； basic helix-loop-helix transcription factor HAND2； class A basic helix-loop-helix protein 26； deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2； 心脏和神经嵴衍生蛋白2；
背景信息：
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
