基因名：
LITAF
产品别名：
PIG7； SIMPLE； TP53I7； LITAF； lipopolysaccharide induced TNF factor； lipopolysaccharide induced TNF factor； lipopolysaccharide-induced tumor necrosis factor-alpha factor； LPS-induced TNF-alpha factor； lipopolysaccharide-induced TNF-alpha factor； p53-induced gene 7 protein； small integral membrane protein of lysosome/late endosome； tumor protein p53 inducible protein 7； 脂多糖诱导肿瘤坏死因子α；
背景信息：
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008]
