基因名:
NCOR1
产品别名:
N-CoR; N-CoR1; PPP1R109; TRAC1; hN-CoR; NCOR1; nuclear receptor corepressor 1; nuclear receptor corepressor 1; nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; thyroid hormone- and retinoic acid receptor-associated corepressor 1; 核受体辅助抑制因子1; 核受体辅抑制因子1(NCOR1);
背景信息:
Nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called silencing mediator for retinoid and thyroid hormone receptor SMRT) is recruited to nuclear and non-nuclear receptors in a large repressing complex containing also N-CoR1, mSin3 and HDACs. This large complex represses transcription in absence of ligand. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Tissue specificity: Ubiquitous. It is belongs to the N-CoR nuclear receptor corepressors family.