基因名：
CEP57
产品别名：
MVA2； PIG8； TSP57； CEP57； centrosomal protein 57； centrosomal protein 57； centrosomal protein of 57 kDa； FGF2-interacting protein； centrosomal protein 57kDa； proliferation-inducing protein 8； testis-specific protein 57； translokin； 57kDa中心体蛋白(CEP57)； 睾丸特异性蛋白57；
背景信息：
CEP57 (centrosomal protein 57kDa), also known as PIG8, TSP57 or Translokin, is a 500 amino acid protein that localizes to both the nucleus and the cytoplasm, specifically associating with microtubules at the centrosome. Expressed ubiquitously, CEP57 exists as a homodimer that functions to mediate the mitogenic activity and nuclear translocation of FGF-2, an internalized growth factor, thereby regulating FGF-2 signaling pathways. Additionally, CEP57 is thought to play a role in spermatogenesis, possibly via the indirect regulation of gene expression. Human CEP57 shares 88% sequence identity with its mouse and bovine orthologs, suggesting a highly conserved role between species. Multiple isoforms of CEP57 exist due to alternative splicing events.
