基因名：
HDAC9
产品别名：
HD7； HD7b； HD9； HDAC； HDAC7； HDAC7B； HDAC9B； HDAC9FL； HDRP； MITR； HDAC9； histone deacetylase 9； histone deacetylase 9； histone deacetylase 9； MEF-2 interacting transcription repressor (MITR) protein； histone deacetylase 4/5-related protein； histone deacetylase 7B； 组蛋白去乙酰化酶9； 组蛋白脱乙酰基酶9(HDAC9)；
背景信息：
HDAC9 (Histone Deacetylase 9) catalyses the deacetylation of lysine residues on the core histones (H2A, H2B, H3 and H4). It belongs to the Class IIa HDAC family, which are key regulators of several developmental and differentiation processes such as cardiac growth. HDAC9 represses MEF2 (myocyte enhancer factor 2)-dependent transcription, playing an important role in cardiac hypertrophy.
The HDAC9 isoform MITR/HDRP lacks active site residues and is therefore catalytically inactive. It represses MEF2-dependent transcription by interacting with HDAC1 and/or HDAC3. MITR/HDRP is thought to play a role in skeletal myogenesis and in heart development. It also protects neurons from apoptosis by inhibiting c-Jun phosphorylation by MAPK10 and by repressing c-Jun transcription through recruitment of HDAC1 to the c-Jun promoter.
