基因名：
RAPGEF5
产品别名：
GFR； MR-GEF； MRGEF； REPAC； RAPGEF5； Rap guanine nucleotide exchange factor 5； Rap guanine nucleotide exchange factor 5； rap guanine nucleotide exchange factor 5； M-Ras-regulated GEF； M-Ras-regulated Rap GEF； Rap guanine nucleotide exchange factor (GEF) 5； guanine nucleotide exchange factor for Rap1； related to Epac； Rap鸟嘌呤核苷酸交换因子(GEF)5；
背景信息：
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
