基因名：
GAB2
产品别名：
GAB2； GRB2 associated binding protein 2； GRB2 associated binding protein 2； GRB2-associated-binding protein 2； Grb2-associated binder 2； growth factor receptor bound protein 2-associated protein 2； pp100； GRB2关联结合蛋白2(GAB2)； 接头蛋白Gab 2； 磷酸化接头蛋白Gab 2； 磷酸化接头蛋白Gab2；
背景信息：
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
