重组激活素受体1蛋白

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重组激活素受体1蛋白

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Recombinant MAGI2
Recombinant membrane associated guanylate kinase, WW and PDZ domain containing 2 protein

基因名：

MAGI2

产品别名：

ACVRIP1； AIP-1； AIP1； ARIP1； MAGI-2； NPHS15； SSCAM； MAGI2； membrane associated guanylate kinase, WW and PDZ domain containing 2； membrane associated guanylate kinase, WW and PDZ domain containing 2； membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2； activin receptor interacting protein 1； atrophin-1-interacting protein 1； atrophin-1-interacting protein A； membrane-associated guanylate kinase inverted 2；激活素受体1；

背景信息：

AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。