基因名：
NR1H4
产品别名：
BAR； FXR； HRR-1； HRR1； PFIC5； RIP14； NR1H4； nuclear receptor subfamily 1 group H member 4； nuclear receptor subfamily 1 group H member 4； bile acid receptor； RXR-interacting protein 14； farnesoid X nuclear receptor； farnesoid X-activated receptor； farnesol receptor HRR-1； retinoid X receptor-interacting protein 14； 胆汁酸受体；
背景信息：
The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
