基因名：
ABI1
产品别名：
ABI-1； ABLBP4； E3B1； NAP1BP； SSH3BP； SSH3BP1； ABI1； abl interactor 1； abl interactor 1； abl interactor 1； Abelson interactor 1； Abl-interactor protein 1 long； abl-binding protein 4； eps8 SH3 domain-binding protein； interactor protein AblBP4； nap1 binding protein； spectrin SH3 domain-binding protein 1； ABI1/SSH3BP1蛋白； Abl交互子1(ABI1)；
背景信息：
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus(v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA (By similarity). Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.
