基因名：
PDCD6IP
产品别名：
AIP1； ALIX； DRIP4； HP95； PDCD6IP； programmed cell death 6 interacting protein； programmed cell death 6 interacting protein； programmed cell death 6-interacting protein； ALG-2 interacting protein 1； ALG-2-interacting protein X； PDCD6-interacting protein； apoptosis-linked gene 2-interacting protein X； dopamine receptor interacting protein 4； 细胞程序性死亡蛋白6相互作用蛋白(PDCD6IP)； 调亡诱导因子6/多巴胺受体4；
背景信息：
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]
