基因名：
EDIL3
产品别名：
DEL1； EDIL3； EGF like repeats and discoidin domains 3； EGF like repeats and discoidin domains 3； EGF-like repeat and discoidin I-like domain-containing protein 3； EGF-like repeats and discoidin I-like domains 3； developmental endothelial locus-1； developmentally-regulated endothelial cell locus 1 protein； integrin-binding protein DEL1； EGF样重复盘状结构I样域蛋白3(EDIL3)； 表皮生长因子样重复折叠1结构域蛋白3；
背景信息：
EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. EDIL3 has been found to be re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence and migration of endothelial cells, and acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. EDIL3 has also been shown to be an endogenous inhibitor of inflammatory cell recruitment by interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion. Human EDIL3 is synthesized as a precursor with a 16 amino acid signal sequence and a 464 amino acid mature chain.
