基因名:
FEM1B
产品别名:
F1A-ALPHA; F1AA; FEM1-beta; FEM1B; fem-1 homolog B; fem-1 homolog B; protein fem-1 homolog B; FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; fem-1-like in apoptotic pathway protein alpha; FIAA蛋白;
背景信息:
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Tissue specificity: Widely expressed. Highly expressed in testis. Weakly expressed in other tissues.