基因名：
RASGRP1
产品别名：
CALDAG-GEFI； CALDAG-GEFII； IMD64； RASGRP； RASGRP1； RAS guanyl releasing protein 1； RAS guanyl releasing protein 1； RAS guanyl-releasing protein 1； RAS guanyl nucleotide-releasing protein 1； RAS guanyl releasing protein 1 (calcium and DAG-regulated)； calcium and DAG-regulated guanine nucleotide exchange factor II； calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II； guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A； ras activator RasGRP； Ras蛋白特异鸟嘌呤核苷酸释放因子1；
背景信息：
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
