基因名：
PATJ
产品别名：
Cipp； INADL； InaD-like； hINADL； PATJ； PATJ crumbs cell polarity complex component； PATJ crumbs cell polarity complex component； inaD-like protein； PALS1-associated tight junction protein； PDZ domain protein； channel-interacting PDZ domain protein； channel-interacting PDZ domain-containing protein； inactivation no after-potential D-like protein； inactivation-no-afterpotential D-like； protein associated to tight junctions； PSD95相关紧密连接蛋白PATJ；
背景信息：
The membranes of myelinating Schwann cells are joined by tight, gap and adherens junctions, all of which are found in regions of noncompact myelin: the paranodal loops, incisures of Schmidt-Lanterman and mesaxons. Tight junctions help establish polarity in mammalian epithelia by forming a physical barrier that separates apical and basolateral membranes. Pals-associated tight junction protein (PATJ), the human homolog of Drosophila Discs Lost, is differentially localized in myelinating Schwann cells. PATJ associates with Claudin-1, CRB1 (a transmembrane protein that plays a role in epithelial cell polarity and photoreceptor development), and Pals1 (a Lin-7 associated protein). The PATJ/Pals1/CRB1 complex can form a tripartite tight junction in epithelial cells crucial to their integrity.
