基因名:
TRIB1
产品别名:
C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1; TRIB1; tribbles pseudokinase 1; tribbles pseudokinase 1; tribbles homolog 1; G-protein-coupled receptor induced protein; G-protein-coupled receptor-induced gene 2 protein; G-protein-coupled receptor-induced protein 2; phosphoprotein regulated by mitogenic pathways; tribbles-like protein 1; G蛋白偶联诱导蛋白2受体;
背景信息:
TRB-1 is a 372 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase superfamily. Expressed ubiquitously with highest expression in bone marrow, thyroid gland, skeletal muscle and pancreas, TRB-1 interacts with MAPK kinases and is thought to regulate the activation of MAP kinses, possibly controlling MAP kinase cascades. The gene encoding TRB-1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.