基因名：
RIDA
产品别名：
HRSP12； P14.5； PSP； UK114； hp14.5； RIDA； reactive intermediate imine deaminase A homolog； reactive intermediate imine deaminase A homolog； 2-iminobutanoate/2-iminopropanoate deaminase； 14.5 kDa translational inhibitor protein； UK114 antigen homolog； heat-responsive protein 12； perchloric acid-soluble protein； ribonuclease UK114； translation inhibitor L-PSP ribonuclease； translational inhibitor p14.5； translational inhibitor protein p14.5； 热反应蛋白12；
背景信息：
Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.
