基因名：
CDK2AP2
产品别名：
DOC-1R； p14； CDK2AP2； cyclin dependent kinase 2 associated protein 2； cyclin dependent kinase 2 associated protein 2； cyclin-dependent kinase 2-associated protein 2； CDK2-associated protein 2； DOC-1-related protein； tumor suppressor deleted in oral cancer related 1； 细胞周期素依赖激酶2相关蛋白2；
背景信息：
CDK2AP2, also known as DOC1R, is short for cyclin-dependent kinase 2-associated protein 2. The gene CDK2AP2 encodes this protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. It belongs to the CDK2AP family. CDK2AP1 (cyclin-dependent kinase 2-associated protein 1), corresponding to the gene doc-1 (deleted in oral cancer 1), is a tumor suppressor protein. The doc-1 gene is absent or down-regulated in hamster oral cancer cells and in many other cancer cell types. The ubiquitously expressed CDK2AP1 protein is the only known specific inhibitor of CDK2, making it an important component of cell cycle regulation during G(1)-to-S phase transition.
