基因名：
STUB1
产品别名：
CHIP； HSPABP2； NY-CO-7； SCA48； SCAR16； SDCCAG7； UBOX1； STUB1； STIP1 homology and U-box containing protein 1； STIP1 homology and U-box containing protein 1； E3 ubiquitin-protein ligase CHIP； CLL-associated antigen KW-8； RING-type E3 ubiquitin transferase CHIP； STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase； antigen NY-CO-7； carboxy terminus of Hsp70-interacting protein； heat shock protein A binding protein 2 (c-terminal)； serologically defined colon cancer antigen 7； E3泛素蛋白连接酶CHIP蛋白； 含STIP1同源物U-框蛋白1(STUB1)；
背景信息：
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
