基因名：
APBB3
产品别名：
FE65L2； SRA； APBB3； amyloid beta precursor protein binding family B member 3； amyloid beta precursor protein binding family B member 3； amyloid-beta A4 precursor protein-binding family B member 3； FE65-like protein 2； amyloid beta (A4) precursor protein-binding, family B, member 3； amyloid precursor interacting protein； protein Fe65-like 2； 淀粉样蛋白β前体蛋白结合蛋白B3(APBB3)； 铁蛋白Fe65样蛋白2；
背景信息：
Fe65L2 is a 486 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the ∫-Amyloid precursor protein, Fe65L2 is thought to modulate the internalization and, therefore, the accessibility and function of ∫-Amyloid. Via its ability to control the intracellular accumulation of ∫-Amyloid, Fe65L2 is thought to play a role in the pathogenesis of Alzheimer's disease. Fe65L2 exists as four alternatively spliced isoforms designated isoform I, isoform II, isoform III and isoform IV. Fe65L2 interacts with Amyloid-like protein and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
