基因名：
TNIP1
产品别名：
ABIN-1； NAF1； VAN； nip40-1； TNIP1； TNFAIP3 interacting protein 1； TNFAIP3 interacting protein 1； TNFAIP3-interacting protein 1； A20-binding inhibitor of NF-kappa-B activation 1； HIV-1 Nef-interacting protein； Nef-associated factor 1 SNP； virion-associated nuclear shuttling protein； 肿瘤坏死因子诱导蛋白31；
背景信息：
Abin-1 is a 636 amino acid protein that localizes to both the nucleus and the cytoplasm and is shuttled between the two intercellular regions in a CRM1-dependent manner. Expressed ubiquitously with highest expression in spleen and skeletal muscle, Abin-1 interacts with A20 and, via this interaction, interferes with TRAF2-mediated transactivation signals and effectively inhibits TNF-induced NFⅹB expression. Additionally, Abin-1 can be incorporated into HIV-1 virions and, if overexpressed, can inhibit viral replication. Abin-1 may also play an important role in the regulation of nuclear import and export activities. Multiple isoforms of Abin-1 exist due to alternative splicing events.
