基因名：
AKR1A1
产品别名：
ALDR1； ALR； ARM； DD3； HEL-S-6； AKR1A1； aldo-keto reductase family 1 member A1； aldo-keto reductase family 1 member A1； aldo-keto reductase family 1 member A1； HEL-S-165mP； alcohol dehydrogenase； aldehyde reductase； dihydrodiol dehydrogenase 3； epididymis secretory protein Li 6； epididymis secretory sperm binding protein Li 165mP； glucuronate reductase； glucuronolactone reductase； NADP依赖的乙醇脱氢酶；
背景信息：
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
