基因名：
IRF9
产品别名：
IRF-9； ISGF3； ISGF3G； p48； IRF9； interferon regulatory factor 9； interferon regulatory factor 9； interferon regulatory factor 9； IFN-alpha-responsive transcription factor subunit； ISGF-3 gamma； ISGF3 p48 subunit； interferon-stimulated gene factor 3 gamma； interferon-stimulated transcription factor 3, gamma (48kD)； interferon-stimulated transcription factor 3, gamma 48kDa； transcriptional regulator ISGF3 subunit gamma； 干扰素调节因子9； 干扰素调节因子9(IRF9)；
背景信息：
Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
