基因名：
C1D
产品别名：
LRP1； Rrp47； SUN-CoR； SUNCOR； hC1D； C1D； C1D nuclear receptor corepressor； C1D nuclear receptor corepressor； nuclear nucleic acid-binding protein C1D； C1D DNA-binding protein； C1D nuclear receptor co-repressor； nuclear DNA-binding protein； small unique nuclear receptor co-repressor； small unique nuclear receptor corepressor； 核DNA结合蛋白C1D；
背景信息：
C1D, also known as SUNCOR, is a nuclear DNA-binding protein that localizes to the nucleus and cytoplasm and participates in processing of the 5.8S rRNA. Expressed ubiquitously with highest expression in thyroid, salivary gland, hippocampus and medulla oblongata, C1D forms a multi-protein complex with MPP6 (M phase phosphoprotein 6) and EXOSC10 (exosome component 10). This complex is responsible, in part, for recruiting the exosome to pre-rRNA and it functions to mediate 3’-5’ rRNA processing. Additionally, C1D can induce transcriptional repression and apoptosis through interaction with Rev-erbα (V-erbA-related protein EAR-1)/TRβ (thyroid hormone receptor β) and p53, respectively. C1D, a 141 amino acid protein, is also implicated in DNA repair mechanisms, as well as DNA-PK (DNA-dependent protein kinase) activation.
